The show's storylines concern the domestic and professional lives of the people who live and work in Erinsborough, a fictional suburb of Melbourne, Victoria. The series primarily centres around the residents of Ramsay Street, a short cul-de-sac, and its neighbouring areas, the Lassiters complex, which includes a bar, hotel, cafe, news office and park. Neighbours began with three families created by Watson – the Ramsays, the Robinsons and the Clarkes. Watson said that he wanted to show three families who are friends living in a small street. The Robinsons and the Ramsays had a long history and were involved in an ongoing rivalry. Pin Oak Court, in Vermont South, is the real cul-de-sac that has doubled for Ramsay Street since 1985. All of the houses featured are real and the residents allow Neighbours to shoot external scenes in their gardens. The interior scenes are filmed at the Global Television studios in Forest Hill.
Through its entire run in Australia, Neighbours has been screened as a twenty-two minute episode each week night in an early-evening slot. In Australia it is currently broadcast each weeknight at 6:30 pm on Eleven. The show is produced by FremantleMedia and has been sold to over fifty countries around the world, making it one of Australia's most successful media exports. Neighbours has proved to be more popular in the United Kingdom and was once the highest-rated daytime programme in the country, outside of news bulletins.